NCCN Publishes New Clinical Practice Guidelines for Myeloproliferative Neoplasms

FORT WASHINGTON, PA—(Marketwired – September 26, 2016) – Myeloproliferative Neoplasms (MPN) are a group of blood cancers characterized by significant symptoms and a high risk of transformation into acute leukemia. These cancers — Myelofibrosis, Essential Thrombocythemia (ET), and Polycythemia vera (PV) — affect approximately 13,000, 134,000, and 148,000 patients in the United States, respectively.[1]

To provide clinicians with the most up–to–date and comprehensive treatment recommendations, the National Comprehensive Cancer Network® (NCCN®) today published the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for MPN to specifically outline diagnosis, treatment, and supportive care strategies for Myelofibrosis. Myelofibrosis is a type of MPN that is the result — in most cases — of one of three genetic mutations within the JAK2 signaling pathway. Comprehensive recommendations for the management of ET and PV will be included in the subsequent versions of the NCCN Guidelines® for MPN.

NCCN Guidelines document evidence–based consensus–driven management to ensure that all patients receive preventive, diagnostic, treatment, and supportive care services that are most likely to lead to optimal outcomes.

“The management of MPNs has been variable in the past and largely driven by review articles and individual opinions. The NCCN Guidelines Panel for MPN hopes these inaugural Guidelines will help leverage the evidence base in MPN care for clear, well–informed, treatment guidelines to hopefully improve quality of care and provide better outcomes for patients with MPN,” said Ruben A. Mesa, MD, FACP, Mayo Clinic Cancer Center, Chair of the NCCN Guidelines Panel for MPN.

Dr. Mesa will present the new NCCN Guidelines in an educational setting during the NCCN 11th Annual Congress: Hematologic Malignancies™ on Friday, September 30, in a session titled, “Myeloprofilerative Neoplasms and Myelofibrosis: Evolving Management.” To register, visit NCCN.org/HEM.

With the publication of the NCCN Guidelines for MPN, the library of NCCN Guidelines now includes 63 clinical guidelines detailing sequential management decisions and interventions that currently apply to 97 percent of cancers affecting people in the United States, as well as cancer prevention, detection and risk reduction, and age–related recommendations.

Available free–of–charge to registered users of NCCN.org and through the Virtual Library of NCCN Guidelines Mobile Apps, NCCN Guidelines help oncologists make the major clinical decisions encountered in managing their patients by providing ready access to synthesized information. The NCCN Guidelines provide recommendations for appropriate care for most, but not all patients; however, all individual patient circumstances must be considered when applying these recommendations.

To access the NCCN Guidelines for MPN, visit NCCN.org.

About the National Comprehensive Cancer Network

The National Comprehensive Cancer Network® (NCCN®), a not–for–profit alliance of 27 of the world's leading cancer centers devoted to patient care, research, and education, is dedicated to improving the quality, effectiveness, and efficiency of cancer care so that patients can live better lives. Through the leadership and expertise of clinical professionals at NCCN Member Institutions, NCCN develops resources that present valuable information to the numerous stakeholders in the health care delivery system. As the arbiter of high–quality cancer care, NCCN promotes the importance of continuous quality improvement and recognizes the significance of creating clinical practice guidelines appropriate for use by patients, clinicians, and other health care decision–makers.

The NCCN Member Institutions are: Fred & Pamela Buffett Cancer Center, Omaha, NE; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute, Cleveland, OH; City of Hope Comprehensive Cancer Center, Los Angeles, CA; Dana–Farber/Brigham and Women's Cancer Center | Massachusetts General Hospital Cancer Center, Boston, MA; Duke Cancer Institute, Durham, NC; Fox Chase Cancer Center, Philadelphia, PA; Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance, Seattle, WA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL; Mayo Clinic Cancer Center, Phoenix/Scottsdale, AZ, Jacksonville, FL, and Rochester, MN; Memorial Sloan Kettering Cancer Center, New York, NY; Moffitt Cancer Center, Tampa, FL; The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute, Columbus, OH; Roswell Park Cancer Institute, Buffalo, NY; Siteman Cancer Center at Barnes–Jewish Hospital and Washington University School of Medicine, St. Louis, MO; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center, Memphis, TN; Stanford Cancer Institute, Stanford, CA; University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL; UC San Diego Moores Cancer Center, La Jolla, CA; UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; University of Colorado Cancer Center, Aurora, CO; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; The University of Texas MD Anderson Cancer Center, Houston, TX; University of Wisconsin Carbone Cancer Center, Madison, WI; Vanderbilt–Ingram Cancer Center, Nashville, TN; and Yale Cancer Center/Smilow Cancer Hospital, New Haven, CT.

Clinicians, visit NCCN.org. Patients and caregivers, visit NCCN.org/patients. Media, visit NCCN.org/news.

[1] Metha J, Wang H, Iqbal SU, Mesa R, Epidemiology of myeloproliferative neoplasms in the United States, Leuk Lymph 2014;55:595–600.

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Independent Study Confirms RedPoint Global Delivers Optimum Precision for Big Data Management

WELLESLEY HILLS, MA and NEW YORK, NY—(Marketwired – September 26, 2016) – When it comes to getting value from data, there is nothing more important than speed and quality — speed delivers relevance; quality delivers accuracy. RedPoint Global, a leading provider of data management and customer engagement technology, today announced findings from a new benchmark study conducted by information management leader MCG Global Services, which revealed leading performance from RedPoint Global's Data Management™ application. The benchmark study not only established that RedPoint's inherent distributed processing design significantly outperforms competing approaches, but also, according to the study's authors, was far simpler to implement and operate.

Findings showed that RedPoint Data Management (DM) exceeded previous benchmarks and client engagements in usability, maturity, data quality, and speed — completing the same workload 550 percent faster than Spark and 1,900 percent faster than a MapReduce–based Tez/Hive approach. Real–life scenarios were used to showcase how important the underlying YARN–based architecture is in exploiting the vast computational power of Hadoop. Organizations looking for the highest levels of compute performance, data quality, and ease of use will appreciate the cost effectiveness, scalability, and RedPoint's overall lower total cost of ownership over other data management platforms for Hadoop.

William McKnight, president of MCG Global Services and co–author of the independent survey, commented: “The RedPoint Data Management benchmark results were beyond what we thought possible — not only did RedPoint surpass previous benchmarks in several key areas, but the installation and setup of RedPoint Data Management Site and Execution Servers and Client tool also took less than 1.5 hours. RedPoint's architecture foundation and finely tuned platform utilizing YARN offer a winning combination for success.”

These results stem from RedPoint's ability to leverage the Hadoop cluster for distributed processing via YARN with minimal overhead. As one of the first certified on Hadoop 2.0, which introduced YARN, RedPoint's platform was designed as a parallel processing architecture. Starting with a high–performance data quality system, RedPoint does not require 'interpreters' like MapReduce or Spark to manage files in Hadoop but does so by using its native engine and, most uniquely, does not generate any code that must then be interpreted. This test proved that RedPoint users could not only load and organize data in Hadoop faster than other solutions, but also do so without needing additional technologies available in the Hadoop ecosystem. RedPoint is also known for delivering its robust technology in the cloud, on–premise, and via hybrid deployments, offering users easy access to flexible compute power.

“RedPoint Data Management delivers an incomparable level of agility and performance more than 15 to 20 times faster than our previous tools,” said Steve Rao, CEO, Farm Market iD. “This is particularly important as we are quickly approaching one quadrillion data points. So obviously, a robust yet flexible solution like RedPoint's is critical for us. The platform has helped us manage complex, high volumes of data with incredible precision all under one application umbrella, allowing us to develop and deliver customized insights in record time without needing another product, programming, or specialized experience.”

Key Findings of the Study and Use Case Results Include:

Web Log Data Analyzed Against Product Orders Use Case

  • RedPoint was able to complete the same workload correlating products ordered with page views and coupon campaign click–throughs on an e–commerce website 550 percent faster than using Spark and 1,900 percent faster than using a MapReduce–based Tez/Hive approach.

Usability: Efficiency, Effectiveness, and Satisfaction

  • Installation and setup of RedPoint DM in Hadoop took less than 1.5 person–hours. Configuration of the Hadoop tools for use with RedPoint DM took less than 0.5 person–hours.
  • RedPoint DM User Interface Satisfaction was rated “Very Easy.” According to the benchmark authors, “In our experience, most other vendor tools rate from easy to moderately difficult.”

Address Standardization and Name Matching Use Case

  • RedPoint's Address Standardization workload processed 10 million records on a three node Hadoop cluster, which will scale proportionately on larger clusters, at a rate of 66,667 records per second.
  • RedPoint's Name Matching was achieved at 58,140 records per second on a three node Hadoop cluster, which will scale proportionately on larger clusters.
  • Typically, these types of data quality activities can take significantly longer using traditional approaches and technologies.

“This benchmark proves something our customers have known all along — that RedPoint is the gold standard for Big Data Management,” said Dale Renner, CEO and founder of RedPoint Global. “RedPoint Data Management is architected specifically for organizations that want to get the most value from their data and need to make decisions at the ever accelerating speed of business. Our unique approach to data management in Hadoop offers supreme performance you simply won't find anywhere else.”

The study, which measured fundamental business problems that typical organizations might encounter, leveraged data management scenarios, including integrating data from transactional systems; solving data ingestion problems related to relational data, web–click logs, and coupon logs; and measuring performance of name matching and address standardization.

Earlier this year, for the second time in a row, RedPoint received the highest score in both the Data Integration and Operational/Transactional Data Quality Use Case categories in Gartner's Critical Capabilities for Data Quality Tools Report[1]. RedPoint also received the second highest scores in Data Migration, Big Data & Analytics and Master Data Management; and the third highest score in Information Governance Initiatives.

To download the benchmark study, visit www.redpoint.net/bigdatabenchmark. RedPoint Global will showcase the benchmark results at Strata + Hadoop World from September 26–28 in booth number 415.

About RedPoint Global Inc.

RedPoint Global offers a comprehensive set of world–class ETL, data quality, and data integration applications that operate in and across both traditional and Hadoop 2.0/YARN environments. The company also offers data–driven customer engagement solutions that help companies derive insights from customer behaviors and create consistent, relevant, and precise messaging across any and all channels. All RedPoint applications offer a unique visual user interface that eliminates the need for programming skills, allowing enterprises to utilize all data to achieve their strategic business goals. For more information, visit www.redpoint.net or email: contact.us@redpoint.net.

Disclaimer:

Gartner does not endorse any vendor, product or service depicted in our research publications, and does not advise technology users to select only those vendors with the highest ratings or other designation. Gartner research publications consist of the opinions of Gartner's research organization and should not be construed as statements of fact. Gartner disclaims all warranties, expressed or implied, with respect to this research, including any warranties of merchantability or fitness for a particular purpose.

[1] Gartner, Critical Capabilities for Data Quality Tools, Ted Friedman, Saul Judah, 18 December 2015